The old development perspective which focuses on physical development, has shifted towards the human paradigm as the main key to development. Improving the quality of human capital has a major influence on increasing a country's economic growth. This study aims to analyze the effect of the components of the Human Development Index on economic growth in the Special Region of Yogyakarta. The components of the human development index in this study include Life Expectancy, Average Length of School and Per Capita Expenditures. This research uses quantitative methods. The type of data used is secondary data with cross section 5 district / city panel data and time series for 10 years, from 2009-2018. The analytical tool used is panel data with the Common Effect model. The results showed that life expectancy had a negative and not significant effect on economic growth, the average length of school had a positive and significant effect on economic growth, per capita expenditure had a negative and significant effect on economic growth and life expectancy, average length of schooling, and per capita expenditure jointly influence economic growth. Keywords: Human Development Inde, Economic Growth, life expectancy, per capita expenditure, panel data