Increasing soybean processing industry into tofu causes the amount of waste produced is increasing. Tofu liquid waste contains high enough organic pollutants and if it is discharged into water bodies it can cause a decrease in water quality and the carrying capacity of the aquatic environment around the tofu industry. Tofu industry liquid waste in general has the characteristics of pH, COD, BOD, which still exceeds the quality standard of wastewater. The research objective was to analyze the effectiveness of Tripikon-S for processing tofu wastewater around the Winongo River in Yogyakarta. After processing tofu wastewater using Tripikon-S, it can be concluded that the COD parameter decreased from 6,955.0 mg/L to 2057.5 mg/L, with an efficiency of 70.41%, the BOD parameter dropped from 2,730.0 mg/L to 687, 0 mg/L, with efficiency of 74.83%, and the pH parameters increase in quality from 3.3 to 4.8 mg/L with an efficiency of 31.25%. Over the course of the process there is a significant increase in efficiency.